Firstly it is worth noting that the severity and frequency of RLS symptoms vary greatly between individuals. Mild RLS may not require medical treatment. Initially reassurance should be offered and lifestyle changes may be useful. Secondary causes must be corrected. Dietary supplementation with iron if anaemia is a cause, mineral supplements (magnesium, potassium and calcium) and good sleep hygiene and habits are useful.

Some drugs may worsen RLS and include antidepressants, calcium blocker drugs (used to treat high blood pressure), anti-nausea medications except domperidone, high intake of caffeine and some antiallergy medications.

The following activities during an attack of RLS may be helpful:

Walking and stretching
Hot or cold bath
Relaxation exercises (biofeedback or yoga)
Having an engaging discussion or activity during sitting to distract mind
Massaging affected limbs