RLS:UK

What is the Differential Diagnosis of RLS?

A number of other disorders may be associated with similar symptoms to those experienced in RLS. In establishing a diagnosis of RLS various tests may be performed to rule out other diagnoses.

The differential diagnosis of RLS
  • Nocturnal leg cramps
  • Akathisia (excessive movements of upper and lower limbs, without specific sensory complaints, any time of day)
  • Peripheral neuropathy (not usually associated with motor restlessness or helped by movement)
  • Vascular disease (such as varicose veins or deep vein thrombosis)
  • Painful legs and moving toes
  • Intermittent claudication
  • Neuroleptic induced akathisia
  • Attention Deficit Hyperactivity Disorder in children "growing pains"
  • Anxiety or generalised anxiety disorder
A list of symptoms reported by patients to describe the discomfort of RLS.
  • Like an electric current
  • The heeby-jeebies
  • Crazy legs
  • Like Coca-Cola bubbling through my veins
  • The gotta-moves
  • Aching in my bones
  • Pulling
  • Elvis Legs
  • Tearing
  • Throbbing
  • Creepy Crawly
  • Pain
  • Like a tooth ache in the legs
  • Growing pains
  • Itching bones
  • Like maggots crawling through my veins
The commonest mimics of RLS are:

Arthritis related pain and discomfort of legs
Leg cramps
Positional discomfort

Adapted from April 2001 Medical Bulletin: Restless Legs Syndrome Foundation, Inc
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